Work

In Vitro Combination of Voriconazole and Miltefosine against Clinically Relevant Molds

Year: 2014

Type: article

Abstract: Invasive infections caused by filamentous fungi are a major threat for immunocompromised patients. Innate/acquired resistance to antifungal drugs might necessitate combination therapies. We assessed the potential combination of voriconazole with miltefosine, an original drug with antifungal activity against 33 clinically relevant mold isolates, including both azole-susceptible and -resistant Aspergillus. Using complete inhibition as an endpoint, interactions were indifferent for 32/33 isolates. An alternative 50% inhibition endpoint showed synergistic interactions for 14/33 isolates. Antagonism was absent.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.03212-14

Authors: S. Imbert, M. Palous, I. Meyer, E. Dannaoui, D. Mazier, A. Datry, A. Fekkar

Institutions: Assistance Publique – Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Hôpital Européen Georges-Pompidou, Université Paris Descartes, Centre d'Immunologie et des Maladies Infectieuses, Université Pierre-et-Marie-Curie

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2014668109

FWCI: 0.918

Cites: 17

Cited by: 32

Related to: 10