Work

Diethylstilboestrol for the treatment of prostate cancer: past, present and future

Year: 2013

Type: review

Abstract: The aim of this review was to discuss the most recent data from current trials of diethylstilboestrol (DES) to identify its present role in advanced prostate cancer treatment as new hormonal therapies emerge. The most relevant clinical studies using DES in castration-refractory prostate cancer (CRPC) were identified from the literature. The safety, efficacy, outcomes and mechanisms of action are summarized. In the age of chemotherapy this review highlights the efficacy of oestrogen therapy in CRPC. The optimal point in the therapeutic pathway at which DES should be prescribed remains to be established.

Source: Scandinavian Journal of Urology

DOI: 10.3109/21681805.2013.861508

Authors: Rafal Turo, Michal Smolski, Rachel Esler, Magda L. Kujawa, Stephen J. Bromage, Neil Oakley, Adebanji Adeyoju, Stephen C. W. Brown, Richard Brough, Andrew Sinclair, Gerald N. Collins

Institutions: Stepping Hill Hospital, Stockport NHS Foundation Trust

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2014833694

FWCI: 0.15

Cites: 93

Cited by: 33

Related to: 10