Work

Detection of melanoma cells in peripheral blood stem cell harvests of patients with progressive metastatic malignant melanoma

Year: 1997

Type: article

Abstract: The detection of melanocyte-specific messenger RNA in patients with malignant melanoma suggests the potential contamination of peripheral blood stem cell (PBSC) harvests by neoplastic cells. In this study, the melanocyte-specific transcripts of tyrosinase and Melan-A/MART-1 were used to detect neoplastic cells in PBSC harvests of nine metastatic malignant melanoma patients. Only one patient's PBSC harvest tested positive for tyrosinase. All harvests were negative for Melan-A/MART-1. Our results suggest that contamination of PBSC harvests with neoplastic cells may not contribute to disease progression following high-dose chemotherapy in advanced malignant melanoma.

Source: British Journal of Haematology

DOI: 10.1046/j.1365-2141.1997.1963015.x

Authors: Michael Probst‐Kepper, Andres Schrader, Jan Buer, Jens Grosse, Matthias Volkenandt, Hans‐Joachim Illiger, Bernd Metzner, Janosch Kadar, Stefan Duensing, Bernd Hertenstein, Arnold Ganser, Jens Atzpodien

Institutions: Medizinische Hochschule Hannover, Ludwig-Maximilians-Universität München, Klinikum Oldenburg

Language: English

Topic: Cutaneous Melanoma Detection and Management

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2015023949

FWCI: 0.77

Cites: 8

Cited by: 8

Related to: 10