Work

Activity of clinafloxacin against multidrug-resistant Enterococcus faecium

Year: 1994

Type: article

Abstract: Enterococci resistant to ampicillin, vancomycin, and/or aminoglycosides are a growing clinical problem. We studied the in vitro activity of the new fluoroquinolone clinafloxacin (PD 127,391) against 15 clinical isolates of multidrug-resistant Enterococcus faecium. In kill-kinetic studies, clinafloxacin (1 microgram/ml) was bactericidal against 7 of 12 susceptible isolates, although substantial regrowth occurred in 4 isolates at 48 h. The addition of ampicillin (20 micrograms/ml) resulted in bactericidal activity in all 12 isolates, and no regrowth was seen. For three isolates resistant to clinafloxacin, effective killing was not observed at these concentrations of antibiotics. Clinafloxacin with ampicillin shows promising activity against many of these multiply resistant enterococci.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.38.7.1668

Authors: S Burney, D Landman, J M Quale

Institutions: United States Department of Veterans Affairs, Veterans Health Administration

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2015659273

FWCI: 3.43

Cites: 13

Cited by: 19

Related to: 10