Nature of 5-ht Receptors in Central Vasomotor Loci
Year: 1967
Type: article
Abstract: Gaddum and Hameed (1) were first to suggest that 5-hydroxytryptamine (5-HT) produces some of its effects by acting on specific receptors. Gaddum and Picarelli (2) established that the guinea pig ileum contains two types of 5-HT receptors, each being blocked by a separate set of blocking agents. The “nervous receptors” (M-receptors) were blocked by morphine, atropine, cocaine and methadone; the other type, the “smooth muscle receptors” (D-receptors) were blocked by dibenzyline, dihydroergotamine and 5-benzyloxygramine. Since then the nature of 5-HT receptors in various organs of the body has been worked out. However, studies on the nature of 5-HT receptors and the effect of various antagonists on the effects of 5-HT in the central nervous system are few. In the present study an attempt has been made to work out the nature of the receptors involved in the central hypotensive response of 5-HT administered in the lateral cerebral ventricle of dogs (3). A preliminary report of this work has already been published (4).
Authors: K.N. DHAWAN, B.N. DHAWAN, G.P. GUPTA
Institutions: University of Lucknow, Central Drug Research Institute
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2015694079