Work

cDNA sequence of human β‐preprotachykinin, the common precursor to substance P and neurokinin A

Year: 1986

Type: article

Abstract: The nucleotide sequence of cDNA encoding the human substance P precursor, beta-preprotachykinin (beta-PPT), has been determined. The source of mRNA was a human laryngeal carcinoid tumour that contained a high concentration of immunoreactive substance P. The human beta-PPT polypeptide is 129 amino acids long and contains regions encoding substance P and neurokinin A, each flanked by basic amino acid residues. Residues 72-107 of the human beta-PPT polypeptide encode the sequence of neuropeptide K, an N-terminally extended form of neurokinin A recently isolated from porcine brain.

Source: FEBS Letters

DOI: 10.1016/0014-5793(86)81534-4

Authors: A.J. Harmar, A. Armstrong, J.C. Pascall, K. Chapman, R. Rosie, A. Curtis, J. Going, C.R.W. Edwards, G. Fink

Institutions: Royal Edinburgh Hospital, University of Edinburgh, Western General Hospital

Language: English

Topic: Neuropeptides and Animal Physiology

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2015696786

FWCI: 3.263

Cites: 16

Cited by: 96

Related to: 10