A Large-Scale Rheumatoid Arthritis Genetic Study Identifies Association at Chr 9q33.2
Year: 2007
Type: article
Study design: Observational Study
Abstract: Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease affecting both joints and extra-articular tissues. Although some genetic risk factors for RA are well-established, most notably HLA-DRB1 and PTPN22, these markers do not fully account for the observed heritability. To identify additional susceptibility loci, we carried out a multi-tiered, case-control association study, genotyping 26,764 putative functional SNPs in 475 white North American RA patients and 475 matched controls. Significant markers were genotyped in two additional, independent, white case-control sample sets (661 cases/1322 controls from North America and 596 cases/705 controls from The Netherlands) identifying a SNP, rs1953126, on 9q33.2 that was significantly associated with RA. Through a comprehensive fine-scale-mapping SNP-selection procedure, 137 additional SNPs in a 668kb region from MEGF9 to STOM on 9q33.2 were chosen for
Author: Steven J. Schrodi
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W2015898653