Work

Stored-Trace Reactivation in Rat Prefrontal Cortex Is Correlated with Down-to-Up State Fluctuation Density

Year: 2010

Type: article

Abstract: Spontaneous reactivation of previously stored patterns of neural activity occurs in hippocampus and neocortex during non-rapid eye movement (NREM) sleep. Notable features of the neocortical local field potential during NREM sleep are high-amplitude, low-frequency thalamocortical oscillations including K-complexes, low-voltage spindles, and high-voltage spindles. Using combined neuronal ensemble and local field potential recordings, we show that prefrontal stored-trace reactivation is correlated with the density of down-to-up state transitions of the population of simultaneously recorded cells, as well as K-complexes and low-voltage spindles in the local field potential. This result strengthens the connection between reactivation and learning, as these same NREM sleep features have been correlated with memory. Although memory trace reactivation is correlated with low-voltage spindles, it is not correlated with high-voltage spindles, indicating that despite their similar frequency characteristics, these two oscillations serve different functions.

Source: Journal of Neuroscience

DOI: 10.1523/jneurosci.1617-09.2010

Authors: Lise A. Johnson, David R. Euston, Masami Tatsuno, Bruce L. McNaughton

Institutions: University of Arizona, University of Lethbridge

Language: English

Topic: Sleep and Wakefulness Research

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Funders: Fondation pour la Recherche Médicale, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke