Work

DNA replication-dependent binding of CTCF plays a critical role in adenovirus genome functions

Year: 2013

Type: article

Abstract: The expression of adenovirus late genes is shown to require viral DNA replication, but its mechanism remains elusive. Here we found that knockdown of CTCF suppresses viral DNA replication as well as late, but not early, gene expression. Chromatin immunoprecipitation assays indicated that CTCF binds to viral chromatin depending on viral DNA replication. These findings depict CTCF as a critical regulator for adenovirus genome functions in late phases of infection.

Source: Scientific Reports

DOI: 10.1038/srep02187

Authors: Tetsuro Komatsu, Takeshi Sekiya, Kyosuke Nagata

Institution: University of Tsukuba

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,690