Year: 1956
Type: article
Abstract: A single subcutaneous injection of adrenaline produces a rise in the concentration of plasma fibrinogen in the rat (Henriques, Henriques, and Mattos, 1950).This rise is proportional to the logarithm of the dose in the range 12.5-200 ttg./ 100 g. body weight.A dose of 50 or 100 ptg.adrenaline, given subcutaneously or intraperiton- eally, caused a marked increase of fibrinogen 24 hr.later, but no change was detected 1, 2, or 4 hr.after administration.This lag between injection and response seems to distinguish the pheno- menon-which had also been reported briefly by Henriques, Henriques, and Selye (1950)-from similar results recorded in the earlier literature.Thus, Riecker and Winters (1931), Goreczky and Kovats (1942), and Suto-Nagy (1944) reported a transitory rise of plasma fibrinogen a few minutes after the administration of adrenaline to dogs or men.Biggs, MacFarlane, and Pilling (1947) have reported a transient increase in fibrinolysis after adrenaline administration to human subjects. This paper describes experiments on the time- relation between treatment and appearance of fibrinogen increase, on the relation between chemical structure and hyperfibrinogenaemic action of sympathomimetic amines, and on the blocking by tolazoline (" Priscol ") of the hyper- fibrinogenaemic effect of adrenaline.
Institution: Instituto Butantan
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2016267269