Work

Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE

Year: 2012

Type: review

Abstract: SLE is an autoimmune inflammatory disease in which various pro- and anti-inflammatory cytokines, including TGF-β, IL-10, BAFF, IL-6, IFN-α, IFN-γ, IL-17, and IL-23, play crucial pathogenic roles. Virtually, all these cytokines can be generated by both innate and adaptive immune cells and exert different effects depending on specific local microenvironment. They can also interact with each other, forming a complex network to maintain delicate immune homeostasis. In this paper, we elaborate on the abnormal secretion and functions of these cytokines in SLE, analyze their potential pathogenic roles, and probe into the possibility of them being utilized as targets for therapy.

Source: BioMed Research International

DOI: 10.1155/2012/347141

Authors: Ding-Lei Su, Zhi-Min Lu, Min-Ning Shen, Xia Li, Ling-Yun Sun

Institutions: Nanjing Drum Tower Hospital, Nanjing First Hospital, Nanjing Medical University, Nanjing University

Language: English

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,680