Toxicity and Outcome of Intensive Chemotherapy for Acute Lymphoblastic Leukemia Complicated with Turner's Syndrome
Year: 2005
Type: article
Study design: Case Report
Abstract: A 17-year-old woman was diagnosed as acute lymphoblastic leukemia (ALL). As she had chromosomal abnormalities of 44, XO, der(9)t(3;9)(q11;p13), der(10;19)(q10;p10), del(15)(q15), -16, -19, +22 with the presence of ovarian dysplasia and abnormal physical features, a diagnosis of Turner's syndrome was made. She received an induction chemotherapy, which consisted of daunorubicin, cyclophosphamide, vincristine, L-asparaginase and prednisolone. Although, severe liver dysfunction was observed, the patient achieved a complete remission (CR) on day 31 following chemotherapy and has maintained CR for more than five years. The recording of such cases may well be of value to clarify toxicity and outcome after chemotherapy for patients with ALL complicated with Turner's syndrome.
Source: Internal Medicine
Authors: Takeshi SAITO, Noriko USUI, Osamu ASAI, Shingo YANO, Katsuki SUGIYAMA, Mamoru HISATOMI, Kyoko UEDA, Nobuaki DOBASHI, Masayuki KOBAYASHI
Institution: Jikei University School of Medicine
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2016439296