Work

Nonwoven Polylactide Scaffolds Obtained by Solution Blow Spinning and the In Vitro Degradation Dynamics

Year: 2013

Type: article

Abstract: The solution blow spinning is presented as a method of obtaining tissue engineering scaffolds. The different forming modes were used and the optimum experimental conditions were found. It is shown that nonwoven polylactide scaffolds with required surface morphology can be obtained. These samples were studied in case of biodegradation in simulation body fluid. It was found that during scaffold dissolution the pH of the solution changes insignificantly (6.85) despite the exponential increase of the monomers of lactic acid. The calcium and phosphorus ion exchange between the scaffold and solution was observed in the surface and bulk of the material what makes possible to use scaffolds for regenerative medicine.

Source: Advanced materials research

DOI: 10.4028/www.scientific.net/amr.872.257

Authors: Sergey Ivanovich Tverdokhlebov, Ksenia Stankevich, Evgeny N. Bolbasov, Igor Khlusov, Irina Kulagina, Konstantin Zaitsev

Institutions: Tomsk Polytechnic University, Siberian State Medical University, Tomsk Scientific Research Institute of Balneology and Physiotherapy

Language: English

Topic: Electrospun Nanofibers in Biomedical Applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: hybrid

OpenAlex ID: W2016561934

FWCI:

Cites: 7

Cited by: 7

Related to: 10