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An unusual case of severe combined immunodeficiency with hypereosinophilia

Year: 1997

Type: article

Abstract: Dams ETHM, Mascart‐Lemone F, Schandené L, van der Meer JWM (University Hospital Nijmegen, Nijmegen, The Netherlands, and Hôpital Erasme, Brussels, Belgium). An unusual case of severe combined immunodeficiency with hypereosinophilia (Case Report). J Intern Med 1997; 242: 267–9. Investigation of the cytokine profile in a 26‐year‐old man, suffering from combined immunodeficiency with hypereosinophilia, revealed high levels of interleukin‐4 and interleukin‐5 and relatively low levels of interleukin‐2 and interferon gamma, consistent with a T‐helper type 2 pattern, as has been reported in Omenn's syndrome. However, some distinct clinical and immunological features suggest that this case may represent a unique disease with specific pathogenesis.

Source: Journal of Internal Medicine

DOI: 10.1046/j.1365-2796.1997.00199.x

Authors: E. Th. M. Dams, F. Mascart‐Lemone, L. Schandené, J. W. M. van der Meer

Institution: Erasmus Hospital

Language: English

Topic: Immunodeficiency and Autoimmune Disorders

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2016984039