Work

The in vitro metabolism of ethinyloestradiol, mestranol and levonorgestrel by human jejunal mucosa.

Year: 1981

Type: article

Abstract: 1 Ethinyloestradiol was extensively metabolised in vitro by human jejunal mucosa to form ethinyloestradiol sulphate. 2 The amount of conjugation was directly related to the weight of biopsy tissue. 3 The degree of conjugation of mestranol and levonorgestrel was much lower than for ethinyloestradiol suggesting that the 17-position of the steroid nucleus is relatively inaccessible for conjugation. 4 No Phase I metabolism of ethinyloestradiol or levonorgestrel was apparent in the conditions used in these experiments.

Source: British Journal of Clinical Pharmacology

DOI: 10.1111/j.1365-2125.1981.tb00534.x

Authors: DJ Back, M Bates, AM Breckenridge, A Ellis, JM Hall, M Maciver, ML Orme, PH Rowe

Institution: University of Liverpool

Language: English

Topic: Pharmacogenetics and Drug Metabolism

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2017171897

FWCI: 2.18

Cites: 11

Cited by: 38

Related to: 10