Work

Polycomb Group Proteins in Cell Cycle Progression and Cancer

Year: 2004

Type: article

Abstract: Epigenetic deregulation of gene expression is emerging as key mechanism in tumorigenesis. Deregulated activity of the chromatin remodeling Polycomb Repressive Complex 2 (PRC2) has recently been shown to be a frequent event in human tumors. Here we discuss these findings and speculate on the role of the PRC2 complex in controlling gene expression during normal cellular proliferation and cancer development.

Source: Cell Cycle

DOI: 10.4161/cc.3.4.773

Authors: Diego Pasini, Adrian P. Bracken, Kristian Helin

Institutions: European Institute of Oncology, University of Copenhagen

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: European Commission, Associazione Italiana per la Ricerca sul Cancro, Fondazione Italiana per la Ricerca sul Cancro