Work

Evolution of Canine Parvovirus Involved Loss and Gain of Feline Host Range

Year: 1996

Type: article

Abstract: Canine parvovirus (CPV) type-2 emerged as a new virus infecting dogs in 1978, and it was probably derived as a variant of feline panleukopenia virus or of a closely related virus infecting another carnivore. CPV type-2 was subsequently replaced in nature by antigenically variant viruses (CPV type-2a and CPV type-2b) which now coexist in dog populations worldwide. We show that CPV type-2 isolates did not replicate in cats, but that both CPV type-2a and CPV type-2b isolates replicated efficiently. About 10% of the viruses isolated from cats with natural parvovirus disease were antigenically indistinguishable from CPV type-2a or type-2b. The capsid protein gene sequence of a 1990 feline parvovirus isolate ("FPV-24") was essentially identical to the sequence of CPV type-2b viruses from dogs. The loss and reacquisition of the feline host range in CPV was most likely due in each case to small numbers of changes in a region of the virus capsid where three protein monomers interact.

Source: Virology

DOI: 10.1006/viro.1996.0021

Authors: UWE TRUYEN, JAMES F. EVERMANN, ELKE VIELER, COLIN R. PARRISH

Institutions: Ludwig-Maximilians-Universität München, Washington State University, Justus-Liebig-Universität Gießen, Cornell University, New York State College of Veterinary Medicine

Language: English

Topic: Animal Virus Infections Studies

Subfield: Animal Science and Zoology

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,160