Work

Modular Synthesis of Radicicol A and Related Resorcylic Acid Lactones, Potent Kinase Inhibitors

Year: 2007

Type: article

Abstract: Short and sweet: A concise and modular synthesis of radicicol A and related resorcylic acid lactones using fluorous isolation technology and immobilized reagents is reported (see scheme, RF=C3H6C6F13, TMSE=2-(trimethylsilyl)ethyl). The compounds are found to be potent (low-nanomolar) inhibitors of selected kinases. Despite their irreversible inactivation of kinases, they show good selectivity amongst a panel of 127 kinases.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200702406

Authors: Pierre‐Yves Dakas, Sofia Barluenga, Frank Totzke, Ute Zirrgiebel, Nicolas Winssinger

Institutions: Centre National de la Recherche Scientifique, Institut de Science et d'Ingénierie Supramoléculaires, Centre d’Etudes Politiques Et sociaLes

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W2017584520

FWCI: 5.795

Cites: 32

Cited by: 78

Related to: 10