Work

Enhancement of Nadph-dependent Lipid Peroxidation Activity by Ethylene-diaminetetraacetic Acid (edta) in the Presence of Ferrous Ion in Rabbit Liver Microsomes

Year: 1977

Type: article

Abstract: The addition of EDTA to the incubation mixture containing rabbit liver microsomes and ferrous ion resulted in 2-fold increase of lipid peroxidation activity. Such an enhancement was not observed in rat liver microsomes. The maximum lipid peroxidation activity seen in rabbit microsomes in the presence of EDTA and ferrous ion was about 80% that seen in rat liver microsomes. From these results, it is likely that low lipid peroxidation activity in rabbit liver microsomes may account for the insufficiency of an EDTA-LIKE FACTORS(S) IN RABBIT LIVER MICROSOMES.

Source: The Japanese Journal of Pharmacology

DOI: 10.1254/jjp.27.653

Authors: Mitsukazu KITADA, Tetsuya KAMATAKI, Haruo KITAGAWA

Institution: Chiba University

Language: English

Topic: Redox biology and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

OpenAlex ID: W2017678148

FWCI: 0.307

Cites: 9

Cited by: 8

Related to: 10