Work

Pushing the Reset Button: Chemical-Induced Conversion of Amniotic Fluid Stem Cells Into a Pluripotent State

Year: 2012

Type: article

Abstract: In an article by Moschidou et al. appearing in this issue of Molecular Therapy, a major step toward factor-free derivation of a pluripotent cell type was made using a c-Kit+ subpopulation of human first-trimester amniotic fluid cells, which could be converted into bona fide induced pluripotent stem (iPS) cells without the ectopic expression of the pluripotency factors.1 After an extended cell culture period and exposure to the histone deacetylase (HDAC) inhibitor valproic acid (VPA), these so-called amniotic fluid stem cells (AFSCs) could be reset into a pluripotent state.

Source: Molecular Therapy

DOI: 10.1038/mt.2012.192

Authors: Sebastian Diecke, Joseph C Wu

Institutions: Stanford Medicine, Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cardiovascular Institute, Stanford University

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500