Alpha-Human Atrial Natriuretic Peptide (α-hANP) Prevents Pulmonary Edema Induced by Arachidonic Acid Treatment in Isolated Perfused Lung from Guinea Pig
Year: 1987
Type: article
Abstract: Protective effect of alpha-human atrial natriuretic peptide (alpha-hANP) on pulmonary edema was investigated using an isolated perfused lung model. Infusion of alpha-hANP (1.7 to 22 ng/ml or 0.56 to 7.3 nM) prevented the edema induced in isolated lung from guinea pig by repeated treatment of 50 micrograms of arachidonic acid at 30 min intervals via the pulmonary artery. The antiedematic action of alpha-hANP was considered to be receptor mediated because the effective concentration was close to the Kd value of the binding of the ANP receptors in the lung homogenate.
DOI: 10.1254/jjp.44.211
Authors: Norio INOMATA, Norio OHNUMA, Mayumi FURUYA, Yujiro HAYASHI, Yasushi KANAI, Takafumi ISHIHARA, Teruhisa NOGUCHI, Hisayuki MATSUO
Institutions: Suntory (Japan), University of Miyazaki
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2018073400