Work

Enhanced Excretion of Fecal Neutral Sterols and the Hypocholesterolemic Property of 4-O-Methylascochlorin in Mice

Year: 1980

Type: article

Abstract: The hypocholesterolemic property of experimental agent 4-O-methylascochlorin (MAC) was examined in male mice.MAC exerted hypocholesterolemic activity without hepatomegaly in mice given MAC mixed in a standard laboratory diet for a week.MAC also significantly reduced plasma total cholesterol (p-TC) in mice when it was administered immediately after meals by gastric intubation in controlled feeding.However, the oral administration through gastric tube was completely ineffective on p-TC in mice with empty stomach.These results suggest a close

Source: Agricultural and Biological Chemistry

DOI: 10.1080/00021369.1980.10864329

Authors: Tomoyoshi Hosokawa, Mikio Sawada, Kunio Ando, Gakuzo Tamura

Institutions: The University of Tokyo, Chugai Pharmaceutical Co., Ltd. (Japan)

Language: English

Topic: Cholesterol and Lipid Metabolism

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2018180967

FWCI:

Cites: 3

Cited by: 6

Related to: 10