Severe neonatal hyporegenerative anemia due to anti-Vw (anti-MNS9) alloantibody
Year: 2009
Type: article
Abstract: Sir,Severe hemolytic disease of the fetus and newborn (HDFN) not related to anti-D (anti-RH1) and requiring intrauterine transfusion or postnatal exchange transfusion are most commonly caused by anti-Kell (anti-K1) and anti-c (anti-RH4) w6x.However, antibodies directed against low incidence antigen (LIA), particularly those resulting from MNS polymorphism can also lead to life threatening complications w5, 7x.In some fetuses or newborns presenting with severe anemia, and more particularly in the presence of anti-Kell (anti-K1) antibodies, suppression of erythropoiesis may be observed.Anemia is associated with reduced reticulocytosis, less erythroblastosis and less severe hyperbilirubinemia when compared with similar hemoglobin levels but related to anti-D (anti-RH1) alloimmunization w9x.These observations have been supported by in vitro analysis, showing that sera containing anti-Kell as well as monoclonal anti-Kell antibodies suppressed the growth of Kell-positive erythroid progenitors w8x.Here, we report a case of severe hyporegenerative anemia, due to an anti-Vw (anti-MNS9), that was not detected by routine screening of alloantibodies during pregnancy.
Source: Journal of Perinatal Medicine
DOI: 10.1515/jpm.2009.071
Institutions: Swiss Red Cross, Centre Hospitalier Universitaire Vaudois
Language: English
Topic: Blood groups and transfusion
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2018399765