Year: 1966
Type: article
Abstract: Although ethyl alcohol has a long medicinal his- tory (1), its precise effects on the cardiovascular system have not been defined.Acute alcohol in- gestion is known to result in triglyceride accumula- tion in the liver, which appears dependent upon an intact sympathetic nervous system (2).Evidence for stimulation of this system after ethanol ingestion has been advanced (3).Since sustained catecholamine infusion has been associated with lipid accumulation in the myocardium (4, 5), a study of the acute effects of ethanol on myocardial metabolism and function has been undertaken in animals considered nutritionally normal.The quantity given produced blood level concentrations usually associated with moderate intoxication. MethodsMongrel male dogs weighing 19 to 22 kg were anes- thetized 18 hours postprandially with morphine sulfate, 3 mg per kg, and pentobarbital (Nembutal), 12 mg per kg, and studied without opening the chest.After in- sertion of an endotracheal tube, respiration was regulated with a Harvard respiratory pump, facilitating the maintenance of arterial oxygen saturation and pH in the normal range.Catheters were placed in the coronary sinus, pulmonary artery, aorta, and left ventricle for *
DOI: 10.1172/jci105340
Authors: R J Regan, G Koroxenidis, C B Moschos, H A Oldewurtel, P H Lehan, H K Hellems
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: American Heart Association
OpenAlex ID: W2018432292