Year: 1992
Type: article
Abstract: The transfer of 3H-TJN-101 to the fetus and milk was studied following single oral administration of 3H-TJN-101 (4 mg/kg) to pregnant or lactating rats. 1. On days 12 and 18 of gestation, the radioactivity in the fetus at 0.75hr after oral dosing was 36% and 50% of the maternal plasma level, respectively. The radioactivity at 24hr after dosing was lower by 2 % and 5 % than that observed at 0.75 hr, respectively. 2. Transfer of radioactivity to milk was observed following oral administration of 3HTJN-101 to lactating rats on day 11 after delivery. The radioactivity in the milk reached the maximum at 0.75hr, which was the first measurement period after dosing, and decreased with a half-life of 1.2hr up to 4hr, and with a half-life of 12hr from 8 to 48hr after dosing. The radioactivity level in the milk was 2.9 times higher than that in plasma as measured simultaneously 0.75hr after the oral dosing ; however, 8hr after dosing, the levels in milk were almost the same as those in plasma. 3. The tissue distribution study on days 12 and 18 gestation, revealed that the total radioactivity levels in the fetus were lower by approximately 50% than those in maternal plasma.
DOI: 10.2133/dmpk.7.495
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2018464086