PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer
Year: 2013
Type: article
Abstract: Small cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis. Expression array analysis of 23 SCLC cases and 42 normal tissues revealed that EZH2 and other PRC2 members were highly expressed in SCLC. ChIP-seq for H3K27me3 suggested that genes with H3K27me3(+) in SCLC were extended not only to PRC2-target genes in ES cells but also to other target genes such as cellular adhesion-related genes. These H3K27me3(+) genes in SCLC were repressed significantly, and introduction of the most repressed gene JUB into SCLC cell line lead to growth inhibition. Shorter overall survival of clinical SCLC cases correlated to repression of JUB alone, or a set of four genes including H3K27me3(+) genes. Treatment with EZH2 inhibitors, DZNep and GSK126, resulted in growth repression of SCLC cell lines. High PRC2 expression was suggested to contribute to gene repression in SCLC, and may play a role in genesis of SCLC.
Source: Scientific Reports
DOI: 10.1038/srep01911
Institutions: Research Center for Advanced Science and Technology, The University of Tokyo, The University of Tokyo, Chiba University, Japan Science and Technology Agency, Tohoku University, Frederick National Laboratory for Cancer Research, National Cancer Institute, The Cancer Institute Hospital, Japanese Foundation For Cancer Research
Language: English
Topic: Lung Cancer Research Studies
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W2018486812