Putative Zinc-Binding Domain of Plant Transcription Factor, AOBP, is Related to DNA-Binding Domains of Steroid Hormone Receptors and GATA1.
Year: 1995
Type: article
Abstract: A possible Zn-binding structure of a plant transcription factor, AOBP, and its mode of DNA-binding are discussed in reference to crystal/solution structures of steroid hormone receptors and GATA1. The amino acid sequence of AOBP (aa36-aa78) has five Cys residues. Cys[aa42] and Cys[aa45] are positioned with the same spacing as those found in the loop region of the reference proteins, while Cys[aa67] and Cys[aa70] in the same spacing as the other two Cys residues in the recognition helix. These, and some other features of the AOBP sequence suggest that this part of the protein folds into a Zn-binding domain, which corresponds to half the DNA-binding domain of a steroid hormone receptor and thereby binds to the target DNA site through an α-helix. Similar sequences are found in several other plant proteins and the evolutionary relation of these proteins and steroid hormone receptors is discussed.
DOI: 10.2183/pjab.71.288
Authors: Yasutomo KISU, Muneharu ESAKA, Masashi SUZUKI
Institutions: Hiroshima University, MRC Laboratory of Molecular Biology
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2018629945