Year: 1968
Type: article
Abstract: A C T A method is described for the mea- surement of total body exchangeable oxygen stores (TBO2).It is based on the dilution of the stable oxygen isotope, 1802, by the body exchangeable oxygen stores under circumstances in which 1802 is introduced in tracer amounts through a re- breathing circuit.The rate of achieving 1802 steady-state equilibrium was evaluated simultane- ously for both arterial and venous blood compart- ments.After evaluation of several simplifying assumptions, TBO2 values in dog, normal man, and anemic patients were measured.The magnitude of the exchangeable nonlung oxygen stores was 11.0 + 3.1 ml/kg (SD) in 5 dogs, 11.9 + 2.1 ml/kg in 10 normal subjects, and 7.0 ± 1.6 ml/kg in 8 patients with severe anemia (hematocrits of 25% or less).This work was presented in part at the 59th Annual meeting of the American Society for Clinical Investigation, Inc., May 1967.
DOI: 10.1172/jci105923
Authors: Carroll E. Cross, Bernard S. Packer, Michael Altman, J. Bernard L. Gee, H. Victor Murdaugh, Eugene D. Robin
Institution: University of Pittsburgh
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: National Institutes of Health
OpenAlex ID: W2018630830