Work

Micafungin Concentrations in the Plasma and Burn Eschar of Severely Burned Patients

Year: 2011

Type: article

Abstract: Micafungin concentrations in plasma and burn eschar after daily intravenous infusion (1 h) of micafungin (200 to 300 mg) were investigated for six patients with severe burns. Micafungin treatment was initiated more than 72 h after the burn injuries. The peak and trough levels in the plasma after the initial administration and repeated administrations for more than 4 days were comparable with or slightly lower than the reported values for healthy volunteers. Micafungin concentrations in the plasma and burn eschar were between 3.6 and >1,000 times higher than the reported MIC(90)s of micafungin against clinically important Candida and Aspergillus species.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.05381-11

Authors: Junichi Sasaki, Satoshi Yamanouchi, Daisuke Kudo, Tomoyuki Endo, Ryosuke Nomura, Kiyotsugu Takuma, Shigeki Kushimoto, Yotaro Shinozawa, Satoshi Kishino, Shingo Hori, Naoki Aikawa

Institutions: Keio University, Tohoku University, International University of Health and Welfare Hospital, Meiji Pharmaceutical University

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2018656142

FWCI: 1.302

Cites: 14

Cited by: 16

Related to: 9