Year: 2012
Type: article
Study design: Observational Study
Abstract: Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population worldwide. Although recent studies have demonstrated strong genetic associations between AMD and SNPs in a number of genes, other modes of regulation are also likely to play a role in the etiology of this disease. We identified a significantly decreased level of methylation on the IL17RC promoter in AMD patients. Furthermore, we showed that hypomethylation of the IL17RC promoter in AMD patients led to an elevated expression of its protein and messenger RNA in peripheral blood as well as in the affected retina and choroid, suggesting that the DNA methylation pattern and expression of IL17RC may potentially serve as a biomarker for the diagnosis of AMD and likely plays a role in disease pathogenesis.
Source: Cell Reports
Authors: Lai Wei, Baoying Liu, Jingsheng Tuo, Defen Shen, Ping Chen, Zhiyu Li, Xunxian Liu, Jia Ni, Pradeep Dagur, H. Nida Sen, Shayma Jawad, Diamond Ling, Stanley Park, Sagarika Chakrabarty, Catherine Meyerle, Elvira Agron, Frederick L. Ferris, Emily Y. Chew, J. Philip McCoy, Emily Blum, Peter J. Francis, Michael L. Klein, Robyn H. Guymer, Paul N. Baird, Chi-Chao Chan, Robert B. Nussenblatt
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,620
Awards: Diagnosis And Treatment Of Ocular Inflammatory Disease (uveitis), Cellular and molecular mechanisms in Age Related Macular Degeneration & Uveitis, Effect of Acupuncture on Epigenetic Regulation of Inflammatory Mediators in Patie, Use Of Microarrays and Epigenetics In Gene Expression Of Uveitis & AMD Patients, Use Of Microarrays and Epigenetics In Gene Expression Of Uveitis & AMD Patients
OpenAlex ID: W2020209902