Work

A simple diastereoselective synthesis of cyclohexylnorstatine and allocyclohexylnorstatine.

Year: 1989

Type: article

Abstract: Cyclohexylnorstatine [(2R, 3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid] (1) and allocyclohexylnorstatine [(2S, 3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid] (2), designed as key amino acids in renin inhibitors, were synthesized diastereoselectively and simply from Boc-L-phenylalaninol.

Source: Chemical and Pharmaceutical Bulletin

DOI: 10.1248/cpb.37.2570

Authors: Hiromu HARADA, Atsushi TSUBAKI, Tetsuhide KAMIJO, Kinji IIZUKA, Yoshiaki KISO

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W2020477343

FWCI: 3.821

Cites:

Cited by: 19

Related to: 10