Year: 2015
Type: editorial
Abstract: Aging is the strongest risk factor for most neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis. As the aging population is increasing, these neurodegenerative disorders are becoming major social issues in many countries. Interestingly, these diseases share a common pathological phenotype; the accumulation of misfolded and aggregated proteins in the brain. Mounting evidence suggests that there are mechanistic links between toxic protein aggregation and neurodegenerative diseases. With a better understanding of the pathogenesis of these disorders, discovery efforts for disease-modifying therapeutics have markedly increased in recent years. This special issue, titled ‘Neurodegenerative diseases and their therapeutic approaches’, discusses the underlying pathogenic mechanisms and therapeutic implications for AD and other age-associated neurodegenerative disorders.
DOI: 10.1038/emm.2015.13
Authors: Jungsu Kim, Inhee Mook-Jung
Institutions: Mayo Clinic, Mayo Clinic in Florida, Seoul National University
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,490
OpenAlex ID: W2021281334