Two Rare Cases of Familial (Mother and Daughter) Adrenocorticotropic Hormone-independent Cushing's Syndrome due to Adrenal Adenoma, as well as the Asynchronous Development of Another Contralateral Adrenal Adenoma in the Mother
Year: 2014
Type: article
Study design: Case Report
Abstract: We herein report two cases involving a mother and daughter who presented with clinical features of Cushing's syndrome (CS) at 50 and 29 years of age, respectively, and were both found to have adrenocorticotropic hormone-independent adrenal adenoma. Furthermore, a new adenoma was detected in the contralateral adrenal gland in the mother 10 years after surgical treatment, when she presented with subclinical CS. The pathogenesis of this disorder, including the presence of unknown genetic abnormalities causing hereditary CS, is currently poorly understood. In this report, we describe our experience with and consider the pathophysiological implications of two rare and very interesting cases of familial CS.
Source: Internal Medicine
Institutions: National Kyushu Medical Center, Kyoto Medical Center
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2021950261