Work

Induction of Pituitary Lactotrope Differentiation by Luteinizing Hormone α Subunit

Year: 1984

Type: article

Abstract: Addition of gonadotropin releasing hormone to cultures of fetal rat pituitary induced differentiation of lactotropes as revealed by immunocytochemistry. Antiserum to luteinizing hormone (LH) (recognizing native LH), but not antiserum to LH-beta (recognizing both native LH and its beta subunit), inhibited this induction. Further addition of highly purified LH-alpha subunit in culture medium also induced lactotrope differentiation. Thus, the alpha subunit may have a specific biological activity of its own with probable practical use in clinical investigations.

Source: Science

DOI: 10.1126/science.6208610

Authors: Martine Bégeot, Fiona J. Hemming, Paul M. Dubois, Yves Combarnous, Maurice P. Dubois, Michel L. Aubert

Institutions: Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, University of Geneva

Language: English

Topic: Hypothalamic control of reproductive hormones

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2022476396

FWCI: 4.82

Cites: 24

Cited by: 125

Related to: 10