Minocycline-Induced Acute Eosinophilic Pneumonia: Controversial Results of Lymphocyte Stimulation Test and Re-challenge Test
Year: 2007
Type: article
Study design: Case Report
Abstract: We report an instructive case of minocycline-induced eosinophilic pneumonia confirmed by re-challenge test, in which a preceding lymphocyte-stimulation test indicated acetaminophen as the etiologic agent. A 55-year-old woman developed high fever and lung infiltrates with pulmonary eosinophilia after exposure to minocycline, acetaminophen, theophylline and procaterol. All of the medicines were discontinued, resulting in prompt improvement. The lymphocyte stimulation tests provided a positive result for acetaminophen, but not for the other medicines; however, a negative result was given by a re-challenge test with acetaminophen. In contrast, symptoms and hypoxemia reappeared when minocycline was re-administered. We would like to emphasize that lymphocyte stimulation test results need to be carefully interpreted for individual drugs.
Source: Internal Medicine
Authors: Emiko Ono, Eishi Miyazaki, Osamu Matsuno, Shin-ichi Nureki, Toshiyuki Okubo, Masaru Ando, Toshihide Kumamoto
Institution: Oita University
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2024315468