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Association of the CCR5 Δ32 variant with juvenile idiopathic arthritis in a meta-analysis

Year: 2011
Type: article
Study design: Systematic Review
Abstract: Background CCR5 is expressed on Th1 cells and may play a role in Rheumatoid Arthritis by recruiting these cells to the synovium, where they drive an inflammatory process. The CCR5Δ32 variant, a deletion variant which leads to a dysfunctional receptor, has been reported in several genetic association studies in Juvenile Idiopathic Arthritis (JIA), with conflicting results. CCL14 is one of the ligands of CCR5 and polymorphisms in the CCL14 gene have been reported to be associated with Systemic Lupus Erythematosus.
DOI: 10.1186/1546-0096-9-s1-p287
Authors: THCM Reinards, HM Albers, DMC Brinkman, SSM Kamphuis, MAJ van Rossum, EPAH Hoppenreijs, HJ Girschick, C Wouters, RK Saurenmann, JJ Houwing-Duistermaat, REM Toes, TWJ Huizinga, R ten Cate, MW Schilham
Institutions: Leiden University Medical Center, Erasmus MC, Amsterdam UMC Location University of Amsterdam, Radboud University Medical Center, University of Würzburg, Universitair Ziekenhuis Leuven, University Children's Hospital Zurich
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,090
OpenAlex ID: W2024940914
FWCI:
Cites:
Cited by: 2
Related to: 9