Work

Changes in Seizure Susceptibility to Local Anesthetics by Repeated Administration of Cocaine and Nomifensine but Not GBR12935. Possible Involvement of Noradrenergic System.

Year: 2000

Type: article

Abstract: We examined cross-sensitization of cocaine and synthetic local anesthetics to their seizure susceptibility after repeated administration. Seizure susceptibility of procaine and lidocaine increased after the end of two days of treatment with a subconvulsive dose of cocaine. Acute treatment with nomifensine but not GBR12935, a specific inhibitor of the dopamine transporter, facilitated lidocaine-induced convulsion. Furthermore, daily treatment with nomifensine for two days enhanced lidocaine-induced convulsion. These results suggest the possible involvement of the brain noradrenergic system in the changes in seizure susceptibility after repeated administration of some local anesthetics.

Source: The Japanese Journal of Pharmacology

DOI: 10.1016/s0021-5198(19)30594-3

Authors: Tomoyuki Sato, Shigeo Kitayama, Katsuya Morita, Tetsurou Ikeda, Toshihiro Dohi

Institution: Hiroshima University

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2024974104

FWCI: 0.223

Cites: 13

Cited by: 6

Related to: 10