Work

Erythropoietin synthesis by tumour tissues in a patient with uterine myoma and erythrocytosis

Year: 2001

Type: article

Abstract: We report a patient with uterine myoma (leiomyoma) and erythrocytosis in whom erythropoietin (Epo) production in the leiomyoma tissue was identified by reverse transcription polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). A 48-year-old Japanese woman with uterine myoma showed marked erythrocytosis (haemoglobin: 20.2 g/dl, haematocrit: 61.1%, red blood cells: 6.51 x 10(12)/1). After hysterectomy, erythrocytosis rapidly disappeared. In the leiomyoma tissue collected from the patient, Epo mRNA expression was confirmed using RT-PCR. Furthermore, ELISA showed that the Epo protein level was significantly increased compared with those in control tissues. It is suggested that the pathogenesis of erythrocytosis in patients with uterine myoma involves ectopic Epo production by leiomyoma tissues.

Source: British Journal of Haematology

DOI: 10.1046/j.1365-2141.2001.02682.x

Authors: Mitsuaki Suzuki, Satoru Takamizawa, Koji Nomaguchi, Shinya Suzu, Muneo Yamada, Takashi Igarashi, Ikuo Sato

Institutions: Morinaga Milk Industry Co., Ltd. (Japan), Jichi Medical University, Jichi Medical University Hospital

Language: English

Topic: Erythropoietin and Anemia Treatment

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2025834262

FWCI: 1.045

Cites: 12

Cited by: 40

Related to: 10