Work

Inhibition of Influenza Virus Ribonucleic Acid Polymerase by Ribavirin Triphosphate

Year: 1977

Type: article

Abstract: Ribavirin 5'-triphosphate (RTP), derived from the broad-spectrum antiviral compound ribavirin (Virazole), can selectively inhibit influenza virus ribonucleic acid polymerase in a cell-free assay. Ribavirin and its 5'-monophosphate have no effect on the polymerase. The inhibition is competitive with respect to adenosine 5'-triphosphate and guanosine 5'-triphosphate. RTP also inhibits ApG- and GpC-stimulated influenza virus ribonucleic acid polymerase. Since ribavirin is phosphorylated in the cell, the inhibition of influenza multiplication in the cell may also be caused by RTP.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.11.6.946

Authors: Bertil Eriksson, Erik Helgstrand, Nils Gunnar Johansson, Alf Larsson, Alfons Misiorny, Jan Olof Noren, Lennart Philipson, Kjell Stenberg, Goran Stening, Stig Stridh, Bo Öberg

Institution: Uppsala University

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2026106960

FWCI: 8.086

Cites: 20

Cited by: 260

Related to: 10