Year: 2012
Type: article
Abstract: During acute viral infections, clearance of the pathogen is followed by the contraction of the anti-viral T cell compartment. In contrast, T cell responses need to be maintained over a longer period of time during chronic viral infections in order to control viral replication and to avoid viral spreading. Much is known about inhibitory signals such as through PD-1 that limit T cell activity during chronic viral infection, but little is known about the stimulatory signals that allow maintenance of anti-viral T cells. Here, we show that the co-stimulatory molecule OX40 (CD134) is critically required in the context of persistent LCMV clone 13 infection. Anti-viral T cells express high levels of OX40 in the presence of their cognate antigen and T cells lacking the OX40 receptor fail to accumulate sufficiently. Moreover, the emergence of T cell dependent germinal center responses and LCMV-specific antibodies are severely impaired. Consequently, OX40-deficient mice fail to control LCMV clone 13 infection over time, highlighting the importance of this signaling pathway during persistent viral infection.
Source: PLoS Pathogens
Institution: La Jolla Institute for Immunology
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,043
Awards: Tfh and SAP and T cell help to B cells, G1657500643, TNFR Members in T Cell Immunity to Vaccinia, How IL-10R blockade can resolve persistent viral infections, Induction and maintenance of regulatory T cells, TNFR Members in T Cell Immunity to Vaccinia, G4126962603, G5156247103, G6269535170, G7008304530, G7306363265, G7445370438, G7569298737, G9000091434
OpenAlex ID: W2027086837