Year: 1998
Type: review
Abstract: Hypoxia-inducible factor 1 (HIF-1) accumulates in the nuclei of mammalian cells exposed to reduced O2 tension in a time- and O2 concentration-dependent manner. HIF-1 plays an important role in O2 homeostasis by activating transcription of genes whose products mediate essential cellular and systemic responses to hypoxia, including erythropoiesis (erythropoietin), glycolysis (glucose transporter-1, aldolase A, enolase 1, lactate dehydrogenase A, phosphofructokinase L, and phosphoglycerate kinase 1), vasculogenesis (vascular endothelial growth factor), and vasodilation (inducible nitric oxide synthase and heme oxygenase 1).
Source: CHEST Journal
Authors: Gregg L. Semenza, Faton Agani, Narayan Iyer, Bing-Hua Jiang, Sandra Leung, Charles Wiener, Aimee Yu
Institutions: Johns Hopkins University, Johns Hopkins Medicine
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,160
OpenAlex ID: W2028314932