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Çocuklarda Kurşun Zehirlenmesi, Oksidatif Stres ve Tiyol Bileşiklerin Antioksidan Etkisi

Year: 2010
Type: article
Abstract: Lead causes a great environmental problem because it’s being widely used in the industry. Chronic lead intoxication is the most important health threat to children in the World and our country. Children have a developing system of cell differentiation and growth that’s more vulnerable to inhibition and damage. They’re far more susceptible to lead neurotoxicity than adults because they absorb a higher fraction of lead and. However, it has indicated that low-level exposures of lead result in neurological damage, cognitive dysfunction, neurobehavioral disorders, hypertension, and renal impairment. The mechanism all of lead has in common involves oxidative damage. Oxidative stress induced by lead is seen mainly in erythrocytes including inhibition of heme and hemoglobin (Hb) synthesis, and changing the erythrocytes morphology and survival. The accumulated aminolevulinic acid (ALA) induces ROS generation and lead also inhibits several enzymes having functional -SH groups and might cause impairment in prooxidant/antioxidant balance of cells, resulting in oxidative damage. Thiols either individually or in a combined therapy, with chelating agents have been observed to have beneficial effects against lead’s detrimental properties in experimental studies. These agents were found to be capable of abating some toxic effects of lead, or they are effective in rebalancing the impaired pro-oxidant/antioxidant ratio following lead exposure. It has been indicated that sulfur containing antioxidants, such as methionine, N-acetylcystein (NAC), α-lipoic acid or homocysteine, have a novel approach to strategies for preventing for lead poisoning in industrial child workers or children living in airpollutions.
DOI: 10.5222/j.child.2010.013
Language: English
Open Access status: green
OpenAlex ID: W2029944151
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Cited by: 8
Related to: 10