Year: 2009
Type: article
Abstract: Xestenone is a marine norditerpenoid found in the northeastern Pacific sponge Xestospongia vanilla. The relative configuration of C-3 and C-7 in xestenone was determined by NOESY spectral analysis. However the relative configuration of C-12 and the absolute configuration of this compound were not determined. The authors have now achieved the total synthesis of xestenone using their developed one-pot synthesis of cyclopentane derivatives employing allyl phenyl sulfone and an epoxy iodide as a key step. The relative and absolute configurations of xestenone were thus successfully determined by this synthesis.
Source: Marine Drugs
DOI: 10.3390/md7040654
Authors: Koichiro Ota, Takao Kurokawa, Etsuko Kawashima, Hiroaki Miyaoka
Institution: Tokyo University of Pharmacy and Life Sciences
Language: English
Subfield: Biotechnology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,499
Funder: University of British Columbia
OpenAlex ID: W2034366271