Work

Discrete regulatory regions control early and late expression of D‐Pax2 during external sensory organ development

Year: 2011

Type: article

Abstract: The transcription factor D-Pax2 is required for the correct differentiation of several cell types in Drosophila sensory systems. While the regulation of its expression in the developing eye has been well studied, little is known about the mechanisms by which the dynamic pattern of D-Pax2 expression in the external sensory organs is achieved. Here we demonstrate that early activation of D-Pax2 in the sensory organ lineage and its maintenance in the trichogen and thecogen cells are governed by separate enhancers. Furthermore, the initial activation is controlled in part by proneural proteins whereas the later maintenance expression is regulated by a positive feedback loop.

Source: Developmental Dynamics

DOI: 10.1002/dvdy.22672

Authors: Seth A. Johnson, Katharine J. Harmon, Sarah G. Smiley, Frances M. Still, Joshua Kavaler

Institution: Colby College

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G1853204378, Comparative Functional Genomics INBRE in Maine, G634933097