Work

Design, Synthesis, Antibacterial and Antifungal Activity of Novel 2‐[(E)‐2‐aryl‐1‐ethenyl]‐3‐(2‐sulfanyl‐1H‐benzo[d]imidazole‐5‐yl)‐3,4‐ dihydro‐4‐quinolinones

Year: 2012

Type: article

Abstract: The novel 2‐[(E)‐2‐aryl‐1‐ethenyl]‐3‐(2‐sulfanyl‐1H‐benzo[d]imidazole‐5‐yl)‐3,4‐ dihydro‐4‐quinolinones (4a‐j) analogs were synthesized by Knoevenagel condensation of a solution of 2‐methyl‐3‐(2‐sulfanyl‐1H‐benzo[d]imidazole‐5‐yl)‐3,4‐dihydro‐4‐quinazolinone (3) with aromatic aldehyde in presence of catalytic amount of piperidine. Compounds (4a‐j) showed significant biological activity against all the standard strains. All the synthesized compounds were characterized on the basis of their IR, 1H NMR, MASS spectroscopic data and elemental analyses. All the compounds have been tested for antimicrobial and antifungal activity by the cup‐plate method.

Source: Journal of Chemistry

DOI: 10.1155/2012/795698

Authors: Anisetti Ravinder Nath, Malladi Srinivas Reddy

Institution: Osmania University

Language: English

Topic: Quinazolinone synthesis and applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,160