Year: 2008
Type: article
Abstract: Dimemorfan (DF) has been known to possess neuroprotective properties. While this promising compound deserves further biological evaluation, synthetic methods have not improved since Murakami group unveiled the synthetic efforts in 1972. Herein a succinct synthesis toward DF from commercially available 3-hydroxymorphinan (3-HM) is disclosed. Other morphinan analogs have been effectively prepared by adopting the similar methodology.
DOI: 10.1248/cpb.56.985
Authors: Jong Yup Kim, Hyoung-Chun Kim, Jeongmin Kim, Jinhwa Lee
Institution: Kangwon National University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W2036699734