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Combination of an Antiviral Drug and Immunomodulation against Hepadnaviral Infection in the Woodchuck Model

Year: 2007
Type: article
Abstract: The essential role of multispecific immune responses for the control of hepatitis B virus (HBV) infection implies the need of multimodal therapeutic strategies for chronic HBV infection, including antiviral chemotherapy and immunomodulation. This hypothesis was tested in the woodchuck model by a combination of lamivudine pretreatment and subsequent immunizations of woodchucks chronically infected with woodchuck hepatitis virus. The immunizations were performed with DNA vaccines or antigen-antibody immune complexes (IC)/DNA vaccines. Immunizations with IC/DNA vaccines led to an anti-woodchuck hepatitis virus surface antibody response and significant reductions of viral load and antigenemia, suggesting that such a strategy may be effective against chronic HBV infection.
DOI: 10.1128/jvi.01613-07
Authors: Mengji Lu, Xin Yao, Yang Xu, Heike Lorenz, Uta Dahmen, Haidong Chi, Olaf Dirsch, Thekla Kemper, Lifang He, Dieter Glebe, Wolfram H. Gerlich, Yumei Wen, Michael Roggendorf
Institutions: Essen University Hospital, Shanghai Medical College of Fudan University, Fudan University, Justus-Liebig-Universität Gießen, University of Cologne, University Hospital Cologne
Language: English
Subfield: Epidemiology
Field: Medicine
Open Access status: green
OpenAlex ID: W2037075005
FWCI: 1.622
Cites: 47
Cited by: 38
Related to: 10