Lack of effect of a high polyunsaturated fat diet on the growth of transplantable colon tumors and on the cytolytic activity of macrophages in rats
Year: 1987
Type: article
Abstract: The effect of a high dietary level of polyunsaturated fat was tested on the growth of three different colon cancer cell lines injected subcutaneously into syngeneic rats.This effect was also tested on the in vitro cytolytic activity of resident peritoneal macrophages, natural or endotoxin and/or indomethacin-modulated.A 12 % corn oil dietary supplement had no effect in any of the cases tested. Introduction.A high level of dietary fat, particularly polyunsaturated fat, has been shown to have a promotional effect on colon carcinogenesis in rodents (Reddy, Weisburger and Winder, 1974 ; Reddy and Maeura, 1984).The proposed mode of action is through the effect of fat on luminal bile acids and the prostaglandin IPG) level (these are synthesized from polyunsaturated fatty acids) which may modulate the immune response (Johnston, 1985).
DOI: 10.1051/rnd:19870805
Institution: Inserm
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2039787481