Work

Inhibition of Experimental Asthma in Man by a New Drug (AH 7725) Active when Given by Mouth

Year: 1974

Type: article

Abstract: A new drug, AH 7725, with properties similar to those of disodium cromoglycate (Intal) has the additional feature of being effective when taken by mouth. Six patients with allergic asthma were studied by bronchial challenge tests with antigen. In every one the drug was found to inhibit (either partially or completely) the immediate-type asthmatic response. Late responses were not influenced. The results were significant at the 0.5% level.These findings suggest that AH 7725 given by mouth may be able to inhibit naturally occurring asthmatic attacks in allergic patients. In this case its particular advantage as a prophylactic drug would lie in the treatment of very young asthmatic children and other patients who cannot take drugs by inhalation.

Source: BMJ

DOI: 10.1136/bmj.2.5910.93

Authors: E. S. K. Assem, J. A. Evans, Monica McAllen

Institutions: University College Hospital, University College London Hospitals NHS Foundation Trust, University College London

Language: English

Topic: Asthma and respiratory diseases

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Wellcome Trust