Work

Late resistance to imatinib therapy in a metastatic gastrointestinal stromal tumour is associated with a second KIT mutation

Year: 2004

Type: article

Abstract: Currently, there are no data on the secondary resistance of gastrointestinal stromal tumours to imatinib. Here, we report a case of metastatic gastrointestinal stromal tumour that relapsed during imatinib therapy. Mutation analysis showed that the imatinib-resistant liver tumour contained two c-kit mutations.

Source: British Journal of Cancer

DOI: 10.1038/sj.bjc.6601819

Authors: T Wakai, T Kanda, S Hirota, A Ohashi, Y Shirai, K Hatakeyama

Institutions: Niigata University Medical and Dental Hospital, Niigata University, Osaka University Hospital, The University of Osaka

Language: English

Topic: Gastrointestinal Tumor Research and Treatment

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,190